Endocrine Abstracts

Background: There is no existing longitudinal study to support ethnicity-specific and body mass index (BMI) category-specific waist circumference (WC) thresholds and their potential clinical utility to assess the risk of obesity-related diseases.Methods: We performed a prospective assessment of 5,852,702 subjects in large-scale population-based cohort dataset obtained from the Korea National Health Insurance System. BMI was categorized into 6 subgroups (...

Beige adipocytes can be induced from white adipocytes (WAT) and precursors upon stimulation by cold temperatures and act like brown adipocytes (BAT) to increase energy expenditure. Most in vivo studies examining the mechanisms for the induction of beige/brown adipocytes have focused on subcutaneous white adipose tissue (sWAT) in the mouse. To better understand the development of beige/brown adipocytes from mammalian sWAT, we induced WAT and BAT from 3T3-L1 preadipocyt...

Background: In the previous study, it was demonstrated that pancreatic steatosis was significantly associated with subclinical atherosclerosis in patients with non-obese T2DM. As the result, it was suggested that pancreatic steatosis might be related to macrovascular complication of T2DM. However, the association of pancreatic steatosis on microvascular complication of T2DM has been unknown.Objective: This study aimed to investigate the relation between ...

Aims: To investigate the mechanism of α-lipoic acid (ALA) on preventing diabetes, we evaluated the effect of ALA on growth regulation and composition of skeletal muscle.Methods: OLETF and LETO rats, aged 24 weeks, were treated with or without ALA (100 mg/kg body weight/day in drinking water) and / or insulin (insulin glargine, 2 U/kg body weight/day; subcutaneous injection) for 8 weeks.Results: The treatment of ALA with or wit...

Objective: Obesity is a well-known risk factor for type 2 diabetes, but few data exist on the association between weight changes and future diabetes risk in non-obese subjects. This study aimed to investigate the effect of weight changes on the incidence of type 2 diabetes in Korea, using prospective nationwide data.Research design and methods: A total of 51 405 non-diabetic subjects were included who had undergone health examinations in 2002 and complet...